Wednesday’s fully loaded 15-game slate in the majors will feature plenty of early games, which means you should be ready to make lineup changes to your fantasy baseball teams as soon as you have the chance to do so. Here are three favorable pitching options to consider this Wednesday, regardless of whether you’re playing a season-long format or a specific DFS contest.
Why You Should Start Kevin Gausman Against the Rockies
Yes, Kevin Gausman is the ace of a depleted Toronto Blue Jays’ staff, and he technically doesn’t fall into the category of being a pitcher you could stream since he should have high ownership in every league. However, this matchup against the Colorado Rockies at Rogers Centre is just too good to pass up. Not only should Gausman be considered a strong starting option for both season-long leagues and DFS formats, but it wouldn’t be surprising if he ends up among the best pitchers on this slate.
He was dominant on Opening Day against the Athletics despite not factoring into the decision, as he allowed one run on one hit while striking out 11 across six innings without issuing a walk. Considering he’ll take on a Rockies lineup that has struck out 46 times in five games, he could be in line for another dominant performance.
Why You Should Trust Matthew Boyd Against the Angels
Matthew Boyd was having a strong showing on Opening Day against the Washington Nationals, but out of nowhere, the wheels fell off completely. As a result, Boyd was tagged with the loss after allowing six runs on six hits and a walk across 3.2 innings, although he did strike out seven.
It was an uneven start to the season for Boyd, who went 14-8 with a 3.21 ERA across 31 regular-season starts (179.2 innings) in 2025. This matchup against the Los Angeles Angels looks favorable on paper.
Even though the Chicago Cubs are coming off a loss on Tuesday, the Angels only mustered two runs in that win, and they’re averaging a mere 4.8 runs per game while hitting a collective .217. This looks like a nice spot for a bounce-back effort for Boyd.
Why Noah Cameron Is a Sleeper Candidate Against the Minnesota Twins
Noah Cameron will make his season debut in this matchup against the Minnesota Twins, and if the 26-year-old southpaw is sharp with his command, he could be an intriguing sleeper candidate for this slate. The Twins are probably one of the weakest lineups in the American League and have hit .200 as a team over their first four games, which is the seventh-worst mark in the majors.
Cameron, who posted a 2.99 ERA with a 1.10 WHIP and 4.17 FIP across 24 starts and 138.1 innings in 2025, could take advantage of the matchup, although for season-long formats, he profiles only as a streaming, matchup-based alternative. As for DFS, he could be a low-salary alternative in case you need to round out your pitching staff in an aces-heavy slate.

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