Chicago Cubs Stack Leads Fantasy Baseball, DFS Advice For Tuesday’s MLB Slate (April 21, 2026)

If you’re looking for the latest DFS and fantasy baseball advice across all formats, we’ve got you covered. Here is a lineup to stack, a potentially productive hitter to consider across your lineups, and a pitcher to stream in case you need an extra arm on your staff. We also offer recommendations on a pitcher you shouldn’t target, regardless of how favorable the matchup looks on paper.

Why You Should Stack the Chicago Cubs’ Offense Against Jesus Luzardo on Tuesday

Entering Tuesday’s fantasy baseball slate, it’s hard to argue with the notion that the Cubs are probably the hottest team in baseball. Their win over the Phillies on Monday pushed their winning streak to six games, and it wouldn’t be shocking if they make it to seven when facing Jesus Luzardo. The Cubs already faced Luzardo this season and destroyed him, with the veteran allowing nine runs (eight earned) on 12 hits and one walk while striking out four over 5.1 innings.

Plus, several Chicago players have had success against Luzardo. There’s Alex Bregman, who has hit .308 with a 1.169 OPS and two homers in 13 at-bats against Luzardo. There’s also the reigning NL Player of the Week, Nico Hoerner, who has hit .294 with an .824 OPS in 17 at-bats against Luzardo. As if that wasn’t enough, the Cubs enter Tuesday with the fifth-best collective OPS in the majors (.741). If you can stack the Cubs, do so with confidence.

Stream Colorado Rockies Shortstop Ezequiel Tovar in DFS

The Rockies are an intriguing team to analyze from a hitting perspective, especially when they’re playing in Coors Field, which happens to be the league’s most hitter-friendly park by a wide margin. If you combine those factors with a favorable matchup, you get a player worth streaming in your lineups.

This time, we’re focusing on Ezequiel Tovar, who also happens to be one of the best players on a below-average Rockies roster. Tovar’s overall numbers are far from appealing, as he enters Tuesday’s action with a .224/.258/.353 slash line and a subpar .611 OPS across 23 games this season. However, he’s faced Randy Vasquez, who will start for the Padres on Tuesday, in 15 at-bats and has delivered impressive numbers with a .533 average and a 1.267 OPS. If you’re looking to bolster your DFS lineups with a player who shouldn’t cost much, Tovar certainly fits the mold.

Why You Should Stream Atlanta Braves Pitcher Reynaldo Lopez

Lopez is far from being the best pitcher in the Atlanta Braves rotation, but it’s hard to ignore what he’s done so far this season. One could say he had his worst start of the 2026 season against the Miami Marlins on April 14, as he allowed four runs (three earned) while striking out six and walking a season-worst three across five innings in a no-decision. But prior to that, he had gone 1-0 with a 1.15 ERA, 0.96 WHIP, and 13 strikeouts and five walks in 15.2 innings in his previous three outings.

Tuesday’s matchup is against the Washington Nationals, and even though the Nats aren’t the worst team in the NL by any means, as they enter Tuesday’s slate with the seventh-best collective OPS in the majors (.727), they’re also overachieving significantly. If Lopez is able to improve his command compared to his last start, he could be in line to deliver another strong showing. If you have the chance to stream Lopez, give him a go.

Why You Should Avoid Starting Simeon Woods Richardson Against the Mets

On paper, it would be wise to at least consider any pitcher starting against the Mets, right? The Mets are in the midst of an 11-game losing streak and have scored an MLB-worst 72 runs, which translates to just 3.27 per game. However, this time, you should fade the possibility of starting Simeon Woods Richardson, who will get the nod for the Twins in Tuesday’s series opener against the Mets.

Quite simply, Woods Richardson has been a disaster this season, as evidenced by his 6.10 ERA. He allowed seven runs (six earned) on 10 hits and three walks over five innings versus the Red Sox in his last outing. Oh, and don’t sleep on the Mets, either. They’re far from having a bad offense, and realistically, they’re too talented to continue struggling at this rate for a long stretch. This looks like the ideal bounce-back game for the Mets, so if you’re looking to consider streaming a pitcher, don’t take a deep look at the Twins right-hander.