Still unsure as to which players you should start in fantasy baseball and DFS contests ahead of Wednesday’s slate? We’ve got you covered with several options. Here are suggestions of a lineup to stack, individual hitters to target, and pitchers to consider as starters with positive matchups, regardless of whether you’re playing DFS or season-long formats.
Why the Detroit Tigers Are a Top Lineup Stack Against Seth Lugo
It’s not easy to stack a lineup in a slate where there are several aces taking the mound, but the success of current Tigers hitters against Seth Lugo is hard to ignore. Even though Lugo has been pitching very well this season, as he owns a 1.53 ERA with a 1.08 WHIP and 7.1 K/9 across 17.2 innings to open the year, he’s had problems against some of the players he’ll be facing this Wednesday.
For instance, Zach McKinstry has hit .267 with a .989 OPS. Javier Baez has gone 7-for-20 with 1 homer and a 1.009 OPS. Wenceel Perez owns a 1.100 OPS in 10 at-bats.
Dillon Dingler (.273, .970 OPS) and Riley Greene (.250, 1.056 OPS, 2 homers) have also been successful against the veteran, who represented Puerto Rico in the 2026 World Baseball Classic. With this evidence, stacking a Tigers lineup might not be the worst idea in Wednesday’s slate.
Why Wyatt Langford Is a Strong DFS Anchor Option on Wednesday
Wyatt Langford was a consensus top-30 pick in most drafts before the start of the 2026 fantasy baseball season, and while he’s enjoying a slow start this season, he’s far from being the only slugger who’s struggling in the early stages of the campaign. Langford is hitting just .161 with a .511 OPS and 1 home run across 58 plate appearances in 2026, but he has a favorable matchup to turn things around when facing J.T. Ginn and the Athletics.
Langford has hit .500 with a 1.045 OPS against Ginn, although all 5 of his hits have been singles. If Langford is looking to bounce back from his slow start and end a 3-for-24 slump, this is a good matchup to do so.
Why You Can Feel Confident Streaming Spencer Arrighetti Against the Rockies
Spencer Arrighetti will make his 2026 season debut on Wednesday, and he couldn’t have asked for a better matchup since he’ll be facing the Colorado Rockies outside of Coors Field. Even though the Rox have had some notable games this season, it’s worth noting that they also have a collective .666 OPS on the road. Plus, current Colorado hitters have gone 3-for-16 against Arrighetti.
Even though the 26-year-old right-hander is a bit of an unknown ahead of his season debut, he should be good enough to limit the Rockies offensively and deliver solid innings for the managers who choose to stream him. As if the favorable matchup wasn’t enough of a reason to stream him, Arrighetti should be available in almost every league since he’s rostered in less than 5% of the leagues overall.
Why Jesus Luzardo Is a Viable DFS Starter Candidate Against the Cubs
Yes, Luzardo has been inconsistent this season, and he’ll be facing a Chicago Cubs offense that has been on the rise of late. However, Luzardo has had some decent success against current Chicago players, and the numbers are just too good to ignore. Not to mention the fact that Luzardo has a 4-0 record with a 2.30 ERA and 50 strikeouts in 7 appearances against the Cubs in his career.
He’s also limited current Cubs hitters to a .181 average with a .622 OPS across 83 at-bats, while posting a 27:14 K:BB. Among the Chicago hitters that have struggled the most against Luzardo, we can find Dansby Swanson (.188, .659 OPS in 16 at-bats), Ian Happ (.154, .543 OPS in 13 at-bats), Seiya Suzuki (.167, .333 OPS in 12 at-bats), and Nico Hoerner (.214, .500 OPS in 14 at-bats). If you have the chance to start Luzardo in DFS contests, and if you have him rostered in your season-long formats, roster him with confidence.
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